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Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies.Applied Sciences Volume 9 Issue 20

Despite the obvious biologic plausibility, the lack of consistent epidemiological evidence might be due to methodological issues including lack of cohort follow-up time into older adulthood (when lung cancer usually becomes clinically manifest), small sample sizes, selection and recall biases, and lack of adjustment for tobacco use in the statistical modeling

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In both the RCT and US adult population, AS smokers did not differ from other brand smokers in levels of TNE, but had higher TNE per cigarette smoked

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