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However, conventional accuracy metrics may overestimate clinical utility given this imbalance, as evidenced by the discrepancy between training set performance (XGBoost F1 = 0.808) and validation metrics (F1 = 0.837)

On the other hand, immobilization may lead to reduction or even complete loss of enzymatic activity [148], as a result of conformational changes or blockage of the active sites due to interactions with the coupling matrix [149-151]

(b) reducing taxes

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