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The authors found evidence of ultrastructural abnormalities in cardiomyocytes, including shrunken nuclei with chromatin condensation and fragmentation (apoptosis), nuclear malformation with extensively convoluted nuclear membranes, myofibrillar derangement, thinning and destruction, intramyocardial lipid accumulation and mitophagy, which are associated with myocardial dysfunction

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Look, the bottom line is, during that same period the state spent $50 billion on healthcare costs related to tobacco and cigarette smoking, Roth said