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It has been shown that MSK1 and MSK2 are required for the induced expression of both IL - 1Ra mRNA and protein, while knocking out MSK in mice was found to result in a decreased IL - 1Ra production [164]

Important factors that could cause actual results to differ materially are set forth in Risk Factors in the Companys Annual Report on Form 10-K filed on March 9, 2023

These results suggest that a feedback regulation may involve IL - 6 , HOTAIR and MALAT1

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