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Gmel, Gerhard (2017)

Is diphenhydramine dangerous
Interestingly, a retrospective cohort study highlighted that cigarette smoking appears to be negatively associated with DIH, which is surprising as induction of CYP2E1 in smokers is expected to increase exposure to toxic metabolites (Zaverucha-do-Valle et al., 2014)
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Cigarillos and cigars also contain nicotine, they are harmful and lead to tobacco addiction

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