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Dabigatran binds to the active site of thrombin, thereby preventing thrombin-induced activation of factors V, VIII, XI, fibrin formation, and thrombin-mediated platelet activation and aggregation [117]

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This pathway appears to have multifactorial oncogenicity, with inflammation being directly associated with LC and with the adverse inflammasome/macrophage activation inducing an overall immunosuppressive cold environment, hostile to T-Cellsproven to be important in LC oncogenesis and malignant potential [89]

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