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UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation
Sandulache VC, Chen Y, Feng L, William WN, Skinner HD, Myers JN, Meyn RE, Li J, Mijiti A, Bankson JA, et al

doi:10.1017/s0021853700022039

Subsequently, inactivated Akt depresses downstream nuclear factor Bcl-2 expression to initiate apoptosis (93)
