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For instance, in a review of the Swedish Rheumatology Register of 1,430 patients treated with methotrexate, current smokers were less likely to achieve a good response at 3 months and at later review date post commencing methotrexate [16]

The BMD approach was first suggested by Crump 17 and was later refined by the US EPA for quantitative risk assessment 18

Duration: 3 min 55 sec

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After the combustion is completed, the solid particles (cigarette smoke) are introduced into the test chamber through the smoke outlet pipe at the end of the cigarette holder