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Half of those who first tried smoking by age 14 were smoking daily in their 20s, compared to 33 percent for those who first tried at age 15 to 17 and 8 percent of those who first tried at 18 to 19

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By 1612, the first harvest of tobacco was exported to England from Rolfe's Varina Farms plantation

95% confidence interval (95% CI), 2.352.51), stroke (HR 1.78, 95% CI 1.731.83), MI or stroke (HR 2.00, 95% CI 1.962.04), and death (HR 1.82, 95% CI 1.791.85) relative to nonsmokers, significantly higher than in 20 PY smokers with initiation age 20