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The high concentrations of nicotine present in Natural American Spirit may be due to the reported use of 100% flue-cured tobacco (PN 54), which has a higher concentration of nicotine than other tobacco types (PNs 5557)

These mass concentrations agree with total particulate matter (TPM) measurements of fresh smoke collected on a filter directly downstream of the cigarette or joint (without dilution or aging due to sampling), which show smoking a marijuana joint produces roughly 3.4 (0.6) times more TPM than a tobacco cigarette following the same HCI routine with six puffs

In a recent mouse model to investigate a synergistic effect of exposure to Cigarette Smoke (CS) in utero and during adolescence on lung function by Drummond et al, it was found that in utero exposure to CS induced significant lung function impairment

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Larsson L, Pehrson C, Dechen T, M