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"Inhaled Drug Therapy 2016: The Year in Review"

[27] They also noted case reports of suicides by nicotine, where adults drank liquid containing up to 1,500 mg of nicotine

The increase in nicotine poisoning in the past decade is also associated with the time vapes became available to the general public in 2007, according to the American Association of Poison Control Centers (AAPCC)

[95] With constant use of nicotine, tolerance occurs at least partially as a result of the development of new nicotinic acetylcholine receptors in the brain
