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that is, it takes an ever-increasing amount of the drug to reach the same levels of euphoria that a smaller initial dose initially delivered

Furthermore F AA and alcohol-related RRs for cancer are derived largely from mortality, rather than morbidity data, and are therefore both likely to be underestimated, particularly in the case of breast cancer where the ratio of incidence to mortality is high (Additional file 1: Table S7) [23]

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95% CI, 0.29-0.69) e-cigarettes in the past 30 days were less likely to switch to other flavored ENDS products, while those who used lemon-flavored (OR = 1.26, 95% CI, 1.01-1.57) and vanilla flavored (OR = 1.29

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