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Investors and shareholders will be able to obtain free copies of the proxy statement/prospectus and other documents filed with the SEC by RAI and BAT through the SECs website at In addition, investors and shareholders will be able to obtain free copies of the proxy statement/prospectus and other documents filed with the SEC by RAI, when available, by contacting RAI Investor Relations at [email protected] or by calling (336) 741-5165 or at RAIs website at www.reynoldsamerican.com, and will be able to obtain free copies of the proxy statement/prospectus and other documents filed with the SEC by BAT, when available, by contacting BAT Investor Relations at [email protected] or by calling +44 (0) 20 7845 1000 or at BATS website at www.bat.com

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Ischemic heart disease For ischemic heart disease, we identified eight unique studies with nine eligible observations used to inform our primary analysis (Fig