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Human relevant NAMs have the potential to efficiently determine whether pre-market technologies should be abandoned due to specific hazard concerns, thereby avoiding unintended human health hazards that may only be identified during post-market surveillance

Nicotines detrimental impact on the cardiovascular system is well documented (9), but pouches introduce nicotine directly into the bloodstream via oral absorption, bypassing pulmonary routes and potentially intensifying systemic effects (10)

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Vocational training, without higher education, was found to also be associated with e-cigarette use in youth in Europe 89

of Queensland, 2007)