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The relevance of HER2 amplification and/or overexpression in NSCLC is less clear, and efforts to target HER2 in patients with NSCLC have been focused mostly on those harbouring activating HER2 mutations, approximately 5458% of which occur in patients who have never smoked 128,129

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Toxicol Appl Pharmacol 230, 150158 [DOI] [PMC free article] [PubMed] [Google Scholar] 33.Kim E, Kang BY, and Kim TS (2005) Inhibition of interleukin- 12 production in mouse macrophages by hydroquinone, a reactive metabolite of benzene, via suppression of nuclear factor-kappaB binding activity