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In March 2018, the US Food and Drug Administration (FDA) issued an advance notice of proposed rulemaking to seek public comment on a potential product standard to lower nicotine in cigarettes to a minimally or non-addictive level
Therefore, -blockers are hypothesized to alter the tumor microenvironment, thereby providing a protective role in cancer (Wrobel et al., 2020
[28] Tobacco harm reduction has been a controversial area of tobacco control
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