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Regular check-ups with your healthcare provider are essential for early diagnosis

Another possible contributor to the observed cigarette smoking-induced epidermal hyperkeratinization is nicotine which has also been shown to increase various differentiation markers including filaggrin, involucrin, TG1 in keratinocytes 19 mediated by the activation of nicotinic acetylcholine receptors abundant in the skin 28

[Google Scholar] 20.Statistics Canada

MMWR Morb Mortal Wkly Rep 2015;64(38):10661070
