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Does nicotine stain
In the first step, the lipophilicity of harmane, harmine, and norharman was assessed to evaluate their ability to penetrate and integrate into the lipid bilayers of cell membranes, thereby facilitating interaction with drug transporters such as P-gp and MRP1

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The widespread distribution of nicotinic receptors explains why nicotine will increase heart rate, blood pressure, and muscle contractions

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