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Cancer Risk: The nicotine in tobacco is a leading cause of various cancers, including lung, throat, mouth, esophageal, bladder, and pancreatic cancer

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We think that while it is clear that different endpoints may yield quite different results, the human MOE for cannabis based on the endpoint psychotropic effects can be seen as general validation of the MOE concept, because the resulting values below 1 are expected as the psychotropic effect is the desired endpoint (and hence the psychotropic threshold dose is exceeded by drug users)