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For example, in IL-1-deficient mice, neither local tumors nor lung metastases developed after localized or intravenous inoculation with melanoma cell lines, which suggests that IL-1-induced inflammation participates in the invasiveness of already existing tumor cells [65]

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And the judge added in the report that UPSs high degree of culpability infers significant penalties are appropriate, saying that UPS largely relied on its size and weak internal procedures to excuse blatantly culpable conduct

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