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Despite the shortcomings, the study fills the research gap by underlining the evidence that ST use has severe implications for the quality functioning of life of women in Bangladesh

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All meta-analyses showed an association between ETS and the risk of having a child with NSOFC, based on the cleft phenotype, risk of bias, and year of publication, with a pooled increased odds ratio of 1.80 (95% CI: 1.512.15)

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