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doi: 10.1111/j.1365-2796.2010.02226.x 64 TengPLiuYDaiYZhangHLiuWTHuJ

Our published work shows that histamine acting via H1R, and in conjunction with TLR2 or TLR4 ligands, synergistically amplifies the expression of COX-2 and IL-6 in endothelial cells with resultant overproduction of PGI 2 , PGE 2 , and IL-6