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In North America, especially in the United States, pod-based systems gained share with early market leaders

Dimensions: 5912 x 5912 px | 50.1 x 50.1 cm | 19.7 x 19.7 inches | 300dpi Date taken: 12 March 2019 Photographer: MOLEKUUL/SCIENCE PHOTO LIBRARY More information: Nicotine tobacco stimulant molecule

Possible mechanisms may be indirect exposure of carcinogenic compounds through the blood stream or bile duct [12, 25] or reduced gastric volume and bile salt reflux, which may damage the main pancreatic duct and lead to cancer [26]

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