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Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines 31 for each of our systematic reviews, we identified studies reporting relative risk (RR) of incidence or mortality from each of the 36 selected outcomes for smokers compared with nonsmokers

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But, "that doesn't mean they're going to win." Kaelan Hollon, a spokeswoman for Reynolds American, the tobacco company that led the 2011 suit, says they are "carefully reviewing the FDA's latest proposal for graphic warnings." "We firmly support public awareness of the harms of smoking cigarettes," she says, "but the manner in which those messages are delivered to the public cannot run afoul of the First Amendment protections that apply to all speakers, including cigarette manufacturers."

This also wouldnt be the first time the UK increased the legal age for buying cigarettes