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This interaction suggests that nicotine salt plus menthol flavoring may play an active role in decreasing Mmp12 expression since nicotine and menthol both have an antagonizing effect on 7nAChR signaling, which is linked to Mmp12 [59, 62]
A large 2011 meta-analysis including 57 observational studies and over 29,000 men found cigarette smoking had adverse effects on all sperm parameters, including semen volume, sperm density, total sperm counts, and percentage of sperm with progressive motility
It can cause asthma in children

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Psychopharmacology 190 , 343352 (2007)
