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We need more research. King agreed with him

Quitting smoking is, of course, the best path forward

However, the lower potency of WS-23 to activate TRPM8 channels compared to menthol 6365 may indicate that other targets, including promiscuous TRP channels outside the M8 subfamily, may be involved in its effects on cells

What Is Nicotine

Nicotine in cigarette smoke activates reward pathways in the brain, temporarily reducing anxiety
