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(Article 9 of the WHO FCTC) METS Laboratory operates under the rigorous European Committee for Standardization (CEN) technical standards and key ISO protocols, including ISO 4387 for total particulate matter determination, ISO 10315 for nicotine content analysis, and ISO 8454 for carbon monoxide measurement in vapor phase

First-generation devices refer to e-cigarettes devices designed to mimic the smoking experience as close as possible

A Call for Smarter Tobacco Control The WHO calls for stronger and faster implementation of its MPOWER package, raising tobacco taxes, banning advertising, expanding cessation services, and closing loopholes that allow nicotine products to reach youth

**Lighting**: use a gas or wooden lighter to ignite the tobacco, avoiding to burn it too quickly.4

Acknowledgements Subject recruiting, survey programming and pre-testing, and data collection were carried out by Gayle Ireland and Mary Johnson, Voccii LLC, Charlotte, NC