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Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N -nitrosonornicotine enantiomers, N -nitrosopiperidine, and N -nitrosopyrrolidine

At high doses, such drugs trigger deliriuma dreamlike insanity usually forgotten after it subsides

Smoking bans in the United Kingdom Sales of cigarettes and smoking in the United Kingdom are being gradually restricted during the first few decades of the 21st century

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For the vast majority of people, any nicotine gum side effects related to the heart and circulation are manageable and temporary