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Professor Kevin Fenton, national director of health and wellbeing at PHE, said: "While Public Health England will carefully consider new studies and continue to be vigilant, the wider body of evidence consistently finds that e-cigarettes are less harmful than smoking

Life Sci 34 : 5765

therefore, we addressed this variability by analysing extreme scenarios based on the upper- and lower-bound life expectancy for smokers and non-smokers which thereby take into account the worst and best-case scenarios respectively (computed based on GBDs all-cause mortalitys upper-bound and lower bound values) as shown in Tables 1 and 2

[11] [12] Available interventions include: Nicotine replacement therapy (NRT) : patches, gum, lozenges, inhalators, or nasal spray to manage withdrawal symptoms

Alo Yeditepe Until recently, nicotine was known only as an addictive substance with no cancer-causing effect, and the production of electronic cigarettes was based on this information