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At the envenomation site, local numbness, ischemia (restricted blood and oxygen flow), cyanosis (bluish-purple hue to the skin) and necrosis (body tissue death) may occur and sometimes involves entire regions of the body

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Their position is more cautious: they regulate vapes as tobacco products (even nicotine-free ones, in some cases) and emphasize that approved cessation tools include nicotine patches, gum, lozenges, inhalers, nasal spray, and prescription medications like varenicline (Chantix) and bupropion (Zyban)

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