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2.8 Dosage Recommendations in Patients with Renal or Hepatic Impairment, or CYP2D6 Poor Metabolizers It may be necessary to reduce the clozapine tablets dosage in patients with significant renal impairment or hepatic impairment, or in CYP2D6 poor metabolizers [see Use in Specific Populations (8.6, 8.7)]
Research indicates that people who smoke cigarettes, cigars, or pipes are 6 times more likely to develop oral cancer
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