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Because detection varies, most medical guidance suggests: Occasional users: Allow several days Regular users: Allow at least one week But again, detection time varies significantly between individuals

Animal studies have found second-hand smoke to be about three to four times more toxic than mainstream smoke 14

When nicotine is metabolized in the body, it is primarily converted into cotinine through enzymatic processes

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This makes it stronger, but also more alkaline (think a higher pH), which can give it a harsher feel, especially in higher nicotine strengths