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while four studies received five yes answers [25, 33, 43, 45] and two received four yes answers [32, 51], thus receiving moderate risk of bias note

The detection of SBS4 (a hallmark of tobacco-induced mutagenesis) in the organoid model indicates that chronic WCSE exposure can elicit molecular alterations resembling those found in smoker-derived tumors, effectively bridging in vitro oxidative adaptation with in vivo mutational landscapes

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San Francisco (CA): Wells Fargo Securities, February 8, 2018
