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The degree to which tax increases and tax differentials among states and localities cause substitution toward ITTP depends on many factors, including the rule of law, enforcement at customs borders and at points of sale, the ease of access to illicit sources, the price differential between licit and illicit cigarettes, and the moral sentiments of the smoker

J Hazard Mater 163(1):302307

You have reduced risk for cancers of the lung, mouth, throat, kidney, bladder, pancreas, stomach, and cervix

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E-cigarettes were a big trend, and most big tobacco companies invested in this market