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Official reference: FDA draft guidance on flavored ENDS applications

Even though self-reports of smoking habits are subject to recall bias, as well as underreporting due to increasing stigma, studies over the years indicate that self-reported cigarette consumption is a valid measure for the assessment of trends in smoking prevalence 61,62

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They found that dogs exposed to cigarette smoke in their homes were six times more likely to develop this bladder cancer than those who lived in a smoke-free environment