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In the last 20 years, smoking had decreased by almost 50 percent

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Exposure of Saos-2 osteoblasts (human osteoblast-like cell line derived from a patient with primary osteosarcoma) to E-cigarette vapour resulted in reduced adherence of Saos-2 osteoblasts to the dental implant surface, potentially due to reduced expression of the adhesion molecule, F-actin [40]

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