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In addition, synthetic (man-made) caffeine is added to some medicines, foods, and drinks
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The double-curing method has its roots in an accidental discovery by Northern Syrian tobacco farmers during the Ottoman Empire
Moreover, its impact on isoforms CYP1A2, CYP2A6, CYP2C8/9/10, CYP2C19, CYP2D6, CYP2E1, CYP3A4, CYP3A4/5, and CYP4A has also been shown to be negligible in vitro
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