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The brain-effect differences between nicotine, cocaine, heroin, morphine Dopamine is essential for survival as it is involved in so many functions including motivation, learning and memorization, since the beginning of time

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It was reported that malic acid possessed a positive effect on the quality of tobacco leaves, while oxalic acid and citric acid would damage the taste of tobacco leaves 28

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The resulting DNA adducts are key to chemical carcinogenesis since they can result in miscoding and permanent mutations