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Moreover, there is increasing evidence that, despite a range of genetic risks for addiction across the population, exposure to sufficiently high doses of a drug for long periods of time can transform someone who has relatively lower genetic loading into an addict

Understanding Substance Abuse: Risks, Signs and Prevention Strategies Substance abuse occurs when alcohol, prescription medications or other legal and illegal substances are used excessively or inappropriately

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In other countries (Sweden, Norway, Iceland), this is mainly due to increasing smoking-attributable mortality in females