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In what Ive read so far, the first explanation seems to get the most attention, but there doesnt seem to be a clear causal path for it.The second and third explanations seem plausible to me, but I havent found the data to support them

In San Francisco, overdose deaths hit a new high of 711 during the first year of the pandemic, with those experiencing homelessness facing some of the highest mortality rates

If necessary, repeat this step up to three times in order to finish synchronization

References: Wright I, Stafford K et al

It is highly risky to vape in a hotel room as most use sensitive optical or ionisation alarms that detect vapour easily