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2006 Reynolds Americans acquisition of American Snuff Company (then Conwood) expanded the organizations portfolio to smokeless tobacco with brand rights such as Kodiak, Cougar, and Grizzly
Glycerol also tested negative in the hypoxanthine-guanine phosphoribosyl transferase mutagenicity assay, sister chromatid exchange assay in Chinese hamster ovary cells, and unscheduled DNA synthesis in rat hepatocytes, at concentrations up to 1 mg/ml (CIR, 2015)
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The number of seizures decreased slightly between 2008 and 2013
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