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As soon as Mr Toulmins advice gained publicity, a surgeon called J T Fisher brought out a blend of Asthmatic Herb Tobacco (though this was considered rather disreputable by proponents of pure stramonium.) By the middle of the nineteenth century, smoking in general was a big thing socially acceptable, manly, and becoming ever easier with the introduction of cigars, cigarettes and matches

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Mainstream cigarette smoke exposure attenuates airway immune inflammatory responses to surrogate and common environmental allergens in mice, despite evidence of increased systemic sensitization