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This is referred to as a thunderclap headache. Additional symptoms can include nausea, vomiting, sensitivity to light, blurred vision, muscle weakness and confusion

3 Nicotine pharmacology and cardiovascular effects 3.1 Mechanisms of nicotine action As detailed by Benowitz (22) in his comprehensive review of nicotine pharmacology, nicotines addictive potential stems from its complex interaction with the nervous system, involving rapid central nervous system penetration and subsequent activation of neural reward pathways