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You can get syphilis by having direct sexual contact with infectious sores (chancre) on the genitals, anus, rectum, lips or mouth through unprotected vaginal, anal, or oral sex with someone who has syphilis

doi:10.1590/s01518-8787.2016050006741

Health effects can be severe

The biochemical processes also lead to immunomodulation and dysregulated repair processes, so the malfunction of macrophages renders individuals more susceptible to infections

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