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While over half of the estimated 440 000 smoking-attributable deaths that occur annually in the USA involve non-malignant cardiovascular and respiratory conditions, smoking-attributable cancers are more recognized and feared

Haddad-Lacle herself is a former smoker

Attachment loss severity was increased by 0.5% by smoking 1 cigarette / day, while smoking up to 10-20 cigarettes increased the clinical attachment loss by 5-10%
teenagers since 2020

Based on this, we utilized tobacco-flavored formulations and chose a nicotine concentration (1.8%) with relevance to the largest proportion of users
