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On September 9, 2021, the FDA finally faced a court-ordered deadline to review millions of premarket applications (known as PMTAs) from e-cigarette manufacturers to determine whether the products are appropriate for the protection of public health. The agency denied the applications of nearly a million flavored products, but more than 9 months after the FDAs deadline, it has yet to act on many of the most popular products with young people

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2021;doi:10.1001/jamaoncol.2021.4949

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