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Macrophages, neutrophils, lymphocytes and dendritic cells may be involved in the pathogenesis of inflammatory disorders in the GI tract

So even without the smoke, nicotine makes surgery and recovery harder on your body, according to the FDA and Mayo Clinic

Roberts EP, Schuster G, Haub S

Analyses within each of four US regions (Supplementary Analysis 3) were also generally consistent with the main findings: the Midwest, South, and West showed a clear cigarette shortfall in the post-period that was correlated with ENDS sales (while the Northeast results were inconclusive due to a discrete event in mid-2016 impairing the models ability to detect a significant cigarette shortfall)