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It saw the clearance by the FDA of the first tobacco products to be commercialized under the premarket tobacco product application (PMTA), a legal requirement for the introduction of any novel tobacco-containing product into the U.S

Recently nicotine pouch products, containing nicotine without other constituents of tobacco, have been marketed as a potentially safer way to consume nicotine compared to smoking or using smokeless tobacco

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As the body becomes dependent on nicotine over time, it can experience withdrawal symptoms when the person attempts to quit or reduce the use of tobacco products