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The harmful chemicals in tobacco, such as nicotine and polycyclic aromatic hydrocarbons, generate toxic metabolites after liver metabolism, leading to oxidative stress and inflammatory responses in hepatocytes, which can cause liver damage 27,28

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18 Discussion Cigarette smoking has been shown to increase serum hemoglobin, increase total lung capacity and stimulate weight loss, factors that all contribute to enhanced performance in endurance sports

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On the contrary, results showed a statistically significant negative correlation between duration of smoking and serum T level, with P value 0.036 and correlation coefficient of 0.169