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While cigarette use has steadily declined by more than half, other forms of nicotine use have expanded, including e-cigarettes and smokeless options

Both this article and the 2008 Update target two principal audiences: first, clinicians including clinicians for whom tobacco-dependence treatment is just one of many activities and second, healthcare administrators, insurers, and purchasers who have the capacity to implement systems changes that support and encourage tobacco-dependence treatments, including reimbursing for these cost-effective treatments

Ethics declarations Ethics approval and consent to participate The study was approved by the Institutional Review Board of Eulji University (EUIRB2018-3) and performed in accordance with the Declaration of Helsinki

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